Altered levels of Reelin and its isoforms in schizophrenia and mood disorders
Author(s):
Fatemi, S. Hossein; Kroll, Jerome L.; Stary, Joel M.
Format:
Journal article
Citation:
Neuroreport: For Rapid Communication Of Neuroscience Research, Volume 12, Issue 15 (2001-10). pp. 3209-3215.
Language:
English
Abstract:
Show that blood levels of Reelin and its isoforms are altered in schizophrenia, bipolar disorder and major depression. The changes include significant increases in 410kDa Reelin moiety (49%) in schizophrenic patients (mean age 40 yrs) of 4 ethnic compositions (Caucasian, Vietnamese, Hmong and Laotian); non-significant increases in depressed patients (mean age 40.5 yrs) (34%); and nonsignificant decreases in bipolar blood patients (mean age 40.6 yrs) (33%). There was a significant increase (90%) in 330kDa Reelin in Caucasian schizophrenics; the depressed value was elevated by 30%, but non-significantly. In contrast, bipolar 330kDa value decreased by 31%. All 180kDa Reelin values varied minimally in schizophrenics. In contrast, the 180kDa Reelin values dropped significantly by 9% and 29% in bipolar and depressed patients, respectively, compared with controls. The alterations in blood Reelin values appear to be specific since levels of 2 other blood proteins, ceruloplasmin and albumin, did not vary significantly between all patients and controls. These findings suggest that blood Reelin levels and its isoforms may be used as potential peripheral markers to diagnose presence of several psychiatric disorders and may also serve as targets for future therapeutic interventions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)